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E-letters: Electronic letters published:
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Re: Fluid Juice Was Not Tested
- Beldeu Singh Sandhu (1 May 2008)
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Fluid Juice Was Not Tested
- Paolo Raggi, MD, Mark Houston, MD, Bruce Cooil, PhD (24 June 2007)
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Juice is More Efficacious than Juice Powder
- 'Afa K. Palu (19 June 2007)
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Beldeu Singh Sandhu, CEO and founder 28-11-4, Tmn Sri Murni, Selangor, 68100, Malaysia
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Your research is fully appreciated and has value as an intervention, especially where fluid juices may not be available. Some fruits grow in temperate regions while some other fruits that are known for cardiovascular benefits are found only in tropical areas. POM juice and starfruit juice have a positive effect on the cardiovascular system and blending them with mandarin orange, carrot and red spinach appear to be quite effective but transporting juices can be relatively more costly. Phytonutrients concentrates are easier and cheaper to transport and easier to store as well. In older people, especially the post-55 group, who generally have lower hormone levels and generally have lower serum antioxidant levels, as these decline with age, adding noni does appear to make a difference as noni is also known for its blood-thinning effects. Another very informative study on the interventional effects of fruits and vegetables was undertaken by researchers in Denmark, Sweden, Netherlands and Belgium. This 25-d intervention study with complete control of dietary intake was performed in 43 healthy male and female nonsmokers who were randomly assigned to 1 of 3 groups. The Fruveg group, the fruit and vegetables (Fruveg) group received 600 g fruit and vegetables/d in addition to the basic diet; the Placebo group received a placebo pill, and the Supplement group received a vitamin pill designed to contain vitamins and minerals corresponding to those in 600 g fruit and vegetables. Biomarkers of oxidative damage to protein and lipids and of antioxidant nutrients and defense enzymes were determined before and during intervention. Glutathione peroxidase activity increased in the Fruveg group only and although plasma lipid oxidation lag times increased during intervention in the Fruveg and supplement groups, the increase was significantly higher in the Fruveg group,(see:Lars O Dragsted et al, 2004, The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers1,2,3,4, American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June). Nano extracts obtained from fruit and vegetables and edible flowers and appropriately formulated for topical sprays, are very rapidly absorbed through the dermis for rapid free radical scavenging activity or for rapidly removing oxidative stress in the human biological system in order to support the healthy antioxidant-driven biochemical pathways in the body. This approach promotes quick relief of pain (even in old wounds and injuries) and much faster healing (including old wounds and surgical scars) and has positive cardiovascular effects including lowering of blood pressure in hypertensive people in 30-45 minutes in uncomplicated hypertension. The beneficial effects are mediated both directly by scavenging the superoxide in the body in general and in the cardiovascular system in particular that prevents the reaction of the superoxide with the nitric oxide (NO) produced in the endothelial cells to form the highly reactive oxidant called the peroxynitrite (ONOO-). When the NO formed in the endothelial cells is biochemically bound to form the ONOO-, it is not available for vasoregulation but instead causes oxidative damage to cell membranes. The ONOO- can also cause oxidative injury to coenzyme Q10 which is a very important enzyme for the pathway in which cellular energy is release from utlizing the ATP molecule. Apart from an interference in the yield of cellular energy, coenzyme Q10 is also an antioxidant enzyme that cam effectively repair cell membranes that have suffered oxidative damage. Maintaining cell wall membrane integrity, is important for various reasons including preventing loss of minerals from cells and transport of macromolecules across cell membranes. Maintaining cell membrane integrity in heart cells prevents cardiovascular disease (CVD). A fuller discussion on the mechanism is discussed in a chapter in the manuscript of the unpublished book to be titled Fenton Medicine. The point of special interest is that when juice, comprising a blend of mandarin orange, starfruit, carrot and red spinach is orally consumed and the topical spray is administered about 15 minutes later, the positive effects are more rapid. And that application also brings very fast relief in people with ordinary headaches provided the solution is sprayed on to the spinal column. In due course, these ediceutical sprays will enter clinical trials and your research in phytonutrient concentrates has drawn attention for possible complimentary use. Increasing glutathione levels prevents apoptosis and increased glutathione peroxidase activity is important to achieve therapeutic results or health benefits and consequently, the sprays have trace amounts of bioavailable selenium and minerals in ionic form. Such minerals are part of the building blocks of biomolecules in cells and minerals such as iron, copper, zinc and managanese are important to catalytically enhance the function of antioxidant enzymes, such as SOD that dismutases the superoxide into oxygen and hydrogen peroxide and the glutathione-catalase system converts the hydrogen peroxide in cells into water and oxygen. Hopefully, you may, in due course test phytonutrient concentrates obtained from the same fruits and vegetables but grown in soils that are relatively richer in selenium for a comparative analysis. Beldeu Singh Porixbiotech Sdn Bhd Conflict of Interest:Involved in nano extracts from food and edible substances (called ediceuticals) at Porixbiotech Sdn Bhd in the new field on Fenton Medicine (further info on internet). |
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Paolo Raggi, MD, Director of Imaging, Emory University Atlanta, GA, 30322, Mark Houston, MD, Bruce Cooil, PhD
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Thank you for your interest in our work and your suggestion. However, the title of your letter is unfortunately misleading since our investigation did not utilize fluid juice nor is there any available evidence of your suggestion in the literature. As you may know, laboratory analysis and potency do not always translate into clinically relevant or equivalent effects due to many biological factors. We used a commercially available encapsulated product described in detail in the manuscript, to supplement the phytonutrient content of subjects’ regular diet. The test product was not substituted for dietary produce. We would highly recommend a similar prospective clinical study to evaluate fluid juice compared to placebo. Perhaps some juice companies would be interested in providing research grants to study the interesting question posed here. Please note that you might have meant to state that volatile compounds evaporate not the non-volatile ones. Conflict of Interest:Received research grants from Juice Plus+NSA, Memphis, TN |
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'Afa K. Palu, Advance Research Scientist Tahitian Noni International Research Center, 84003
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I read the article with much excitement due in part to the efficacy shown by the juice powder concentrate on high blood pressure and other factors such as Co-Q10 but wonder if the efficacy shown by Houston et al (2007) could have been much better if they used the phytonutrients in the juice form instead of powder form in capsules. Researches by others in Noni fruit juices and Noni fruit freeze-dried have shown that freeze-dried fruit juices are less potent and therefore less effacacious that the fruit juices itself. The reduced efficacy is due in part to the evaporation of non volatile compounds that may have contributed to the observed activities. It will be very interesting to see the differences in the results if Houton and Colleagues can repeat their human clinical research using phytonutients in the juice form instead of the powder forms. Sincerely, 'Afa K. Palu Conflict of Interest:I work for Tahitian Noni International, Inc. |
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