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eCAM Advance Access published online on July 7, 2009
eCAM, doi:10.1093/ecam/nep080
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina

Saikat Dewanjee, Anup Maiti, Ranabir Sahu, Tarun K. Dua and Vivekananda Mandal

Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India

The matured fruits of Diospyros peregrina are successfully employed by the traditional healers and local people of costal West Bengal, India for the treatment of diabetes. Present investigation was undertaken to evaluate the role of hydroalcoholic extract of D. peregrina (HDP) on type 2 diabetes as well as the augmented oxidative stresses associated with it. Oral administration of HDP at 25, 50 and 100 mg kg–1 body weight per day to diabetic rats was found to possess significant dose-dependent hypoglycemic and hypolipidemic activity. The diabetic rats showed lower activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) content in hepatic and renal tissues as compared to normal rats. The activities of SOD, CAT and GSH were found to be increased in extract-treated diabetic rats in selected tissues. The increased level of lipid peroxidation (thiobarbituric acid reactive substances) in diabetic rats was also found to be reverted back to near normal status in extract-treated groups. Thus it may be concluded that the HDP may produce its hypoglycemic effect through antioxidant defense mechanism.

Keywords: antioxidant – Diospyros peregrina – hypoglycemic activity

For reprints and all correspondence: Saikat Dewanjee, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Tel: +91-33-24146126; Fax: +91-33-28371078; E-mail: s.dewanjee{at}yahoo.com

Received November 25, 2008; accepted May 28, 2009


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