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eCAM Advance Access published online on April 1, 2009
eCAM, doi:10.1093/ecam/nep018
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

Fang-Pey Chen1,2, Maw-Shiou Jong1,2, Yu-Chun Chen2,3, Yen-Ying Kung1,2, Tzeng-Ji Chen2,3, Fun-Jou Chen4 and Shinn-Jang Hwang2,3

1Center for Traditional Medicine, Taipei Veterans General Hospital, 2National Yang-Ming University School of Medicine, Taipei, 3Department of Family Medicine, Taipei Veterans General Hospital and 4Graduate Institute of Integration Chinese and Western Medicine, Chinese Medical University, Taichung, Taiwan

Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%). In addition, female subjects used CHMs for insomnia more frequently than male subjects (female:male = 1.94:1). There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum) was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia.

Keywords: Chinese herbal medicine – insomnia – pharmaco-epidemiology – traditional Chinese medicine

For reprints and all correspondence: Prof. Shinn-Jang Hwang, Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan, ROC. Tel: +886-2-287-57460; Fax: +886-2-287-37901; E-mail: sjhwang{at}vghtpe.gov.tw

Received August 14, 2008; accepted February 12, 2009


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