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eCAM Advance Access published online on March 12, 2007
eCAM, doi:10.1093/ecam/nem015
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice

Yuba Raj Pokharel1, Sung Chul Lim2, Sang Chan Kim3, Tae-Hwe Heo4, Hoo Kyun Choi1 and Keon Wook Kang1

1BK21 Project Team, College of Pharmacy and 2Department of Pathology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, 3Department of Prescription, College of Oriental Medicine, Daegu Haany University, Daegu 706-060 and 4College of Biomedical Laboratory Science, Konyang University, Daejeon, South Korea

Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-{alpha} (TNF-{alpha}) and interferon-{gamma} (IFN-{gamma}). Activation of the nuclear factor-{kappa}B (NF-{kappa}B) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-{kappa}B activation, which may be essential for TARC expression in TNF-{alpha}/IFN-{gamma} treated keratinocytes. The inhibitory effect of SYT on NF-{kappa}B activation and TARC production might be associated with the anti-dermatitic effects of SYT.

Keywords: anti-dermatitic activity – atopic dermatitis – NF-{kappa}B – Sopungyangjae-Tang – TARC

For reprints and all correspondence: Dr Keon Wook Kang, College of Pharmacy, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, South Korea. Tel: +82-62-2306368; Fax: +82-62-2225414; E-mail: kwkang{at}chosun.ac.kr

Received July 3, 2006; accepted January 16, 2007


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