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eCAM Advance Access published online on April 4, 2007
eCAM, doi:10.1093/ecam/nem004
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats

Somashekar Shetty1, Saraswati Udupa2 and Laxminarayana Udupa3

1Department of Biochemistry, Melaka Manipal Medical College, 2Department of Biochemistry, KMC International Centre and 3Department of Pharmacology, Kasturba Medical College, Manipal 576104, India

In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Ocimum sanctum (O. sanctum), a plant widely used in Ayurveda, possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential of alcoholic and aqueous extracts in wound healing in Wistar albino rats. The rats were divided into five groups of six animals each. Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum. The wound healing parameters were evaluated by using incision, excision and dead space wounds in extract-treated rats and controls. Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group. The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

Keywords: antioxidant property – Ocimum sanctum – wound healing activity

For reprints and all correspondence: Dr Somashekar Shetty, Assistant Professor in Biochemistry, Melaka Manipal Medical College, Manipal, India 576 104. Tel: 91-820-2571201; Extn. 22643; Fax: 91-820-2571905; E-mail: somashekarshetty{at}yahoo.com

Received June 15, 2006; accepted January 11, 2007


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