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eCAM Advance Access published online on December 12, 2006
eCAM, doi:10.1093/ecam/nel102
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© 2006 The Author(s).
Received July 5, 2006
Accepted October 30, 2006

Original Article

Indigofera suffruticosa: An Alternative Anticancer Therapy

Jeymesson Raphael Cardoso Vieira 1, Ivone Antônia de Souza 2, Silene Carneiro do Nascimento 2, and Sônia Pereira Leite 3 *

1 Universidade Federal de Pernambuco/Departamento de Patologia do Centro de Ciências da Saúde Recife-PE, Recife-PE, Brazil
2 Universidade Federal de Pernambuco/Departamento de Antibióticos do Centro de Ciências Biológicas, Recife-PE, Brazil
3 Universidade Federal de Pernambuco/Departamento de Histologia e Embriologia do Centro de Ciências Biológicas, Recife-PE, Brazil

* To whom correspondence should be addressed.
Sônia Pereira Leite, E-mail: spl{at}ufpe.br


  Abstract

Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves of I. suffruticosa obtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg-1 (intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves of I. suffruticosa may be used as an alternative anticancer agent.

Keywords: antitumor; aqueous extract; cytotoxicity; Indigofera suffruticosa; toxicity.
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