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eCAM Advance Access published online on December 12, 2006
eCAM, doi:10.1093/ecam/nel099
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© 2006 The Author(s).
Received May 15, 2006
Accepted October 30, 2006

Original Article

In Vitro Anti-Candida Activity of Zataria multiflora Boiss

Ali Zarei Mahmoudabadi 1 *, Muhammad Ali Dabbagh 2, and Zahra Fouladi 3

1 Department of Medical Mycoparasitology, School of Medicine, Jundishapour University of Medical Sciences, Ahwaz, Iran
2 School of Pharmacy, Jundishapour University of Medical Sciences, Ahwaz, Iran
3 School of Nursing and Midwifery, Jundishapour University of Medical Sciences, Ahwaz, Iran

* To whom correspondence should be addressed.
Ali Zarei Mahmoudabadi, E-mail: zarei40{at}hotmail.com


  Abstract

Zataria multiflora Boiss known as Avishan Shirazi (in Iran) is one of the valuable Iranian medicinal plants. The aim of study was to evaluate anti-Candida activity of Z. multiflora against different species of Candida in vitro. Anti-Candida activity of the aqueous, ethanolic and methanolic maceration extract of the aerial parts of Z. multiflora Boiss was studied in vitro. Anti-Candida activity against Candida species was done using serial dilutions of extracts in Sabouraud's dextrose agar. Minimal inhibitory concentration (MIC) of the methanolic and ethanolic extracts was 70.7 and 127 mg l-1, respectively. Aqueous extract showed no remarkable activity against Candida species. We conclude that methanolic extract of the aerial parts of Z. multiflora Boiss has more anti-Candida effect at 70.7 mg l-1 compared to ethanolic extract 127 mg l-1. In addition, the isolates of Candida parapsilosis were more susceptible to methanolic extract than other tested species.

Keywords: anti-Candida; Candida; herbal medicine; Zataria multiflora Boiss.
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