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eCAM Advance Access published online on November 24, 2006
eCAM, doi:10.1093/ecam/nel088
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© 2006 The Author(s).
Received February 1, 2006
Accepted October 12, 2006

Original Article

Nourishing Yin and Promoting Blood Circulation of TCM to Treat Hemorheologic Disorder Induced by Diabetes Mellitus in Rats

Rong Xia 1 *, Ping Huang 2, and Guo-ming Shao 3

1 Department of Basic Medicine, Zhejiang Chinese Medical University, Binjiang, Hangzhou 310053, Zhejiang Province, China
2 Department of Endocrinology, Affiliated Hospital of Zhejiang Chinese Medical University, Youdianlu, Hangzhou 310005, Zhejiang Province, China
3 Department of Laboratory, Affiliated Hospital of Zhejiang Chinese Medical University, Youdianlu, Hangzhou 310005, Zhejiang Province, China

* To whom correspondence should be addressed.
Rong Xia, E-mail: xiarong248{at}hotmail.com


  Abstract

Diabetes mellitus, DM, is commonly accompanied with various stages of hemorheologic disturbances that are the main causes of the development of chronic DM. In this study, simple Chinese material medica [yang-yin jiang-tang preparation (YYJT)] was given to alloxan-induced DM rats and analyzed to compare the changes of fasting blood glucose (FBG), fasting insulin (FINS), hemorheologic parameters and insulin-like growth factor II (IGF-II) before and after administration. The results suggested that YYJT can significantly downregulate FBG (P < 0.005), improve insulin resistance and beta-cell secretion (P < 0.05), decrease whole blood viscosity at low and high shear rates, gathering of blood index test (GIT) and fibrinogen (FIB) (P < 0.05), and enlarge the function of IGF-II (P < 0.05). We concluded that YYJT could prevent and treat hemorheologic disorder in DM rats by means of reducing glucose, improving insulin resistance and elevating IGF-II.

Keywords: Chinese material medica; diabetes mellitus rat; hemorheology; insulin resistance; insulin secretion; insulin-like growth factor II.
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