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eCAM Advance Access published online on October 27, 2006
eCAM, doi:10.1093/ecam/nel075
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© 2006 The Author(s).
Received January 24, 2006
Accepted September 19, 2006

Review

DNA Microarrays in Herbal Drug Research

Preeti Chavan 1, Kalpana Joshi 1, and Bhushan Patwardhan 1 *

1 Bioprospecting Laboratory, Interdisciplinary School of Health Sciences, University of Pune, Pune 411007, India

* To whom correspondence should be addressed.
Bhushan Patwardhan, E-mail: bhushan{at}unipune.ernet.in


  Abstract

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.

Keywords: Drug discovery; evidence-based medicine; gene expression; genotyping; pharmacodynamics; transcription profiling.
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