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eCAM Advance Access published online on September 14, 2006
eCAM, doi:10.1093/ecam/nel051
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© 2006 The Author(s).
Received January 10, 2006
Accepted June 19, 2006

Original Article

Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease

Leila Ashtaral Nakhai 1, Azadeh Mohammadirad 1, Narges Yasa 2, Bagher Minaie 3, Shekoufeh Nikfar 1, Ghazal Ghazanfari 1, Mohammad Jafar Zamani 1, Gholamreza Dehghan 1, Hamidreza Jamshidi 1, Vahid Shetab Boushehri 1, Reza Khorasani 1, and Mohammad Abdollahi 1 *

1 Laboratory of Toxicology, Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Laboratory of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Laboratory of Histopathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

* To whom correspondence should be addressed.
Mohammad Abdollahi, E-mail: mohammad.abdollahi{at}utoronto.ca; mohammad@tums.ac.ir


  Abstract

Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Zataria multiflora Boiss, a folk medicinal plant on prevention and treatment of experimental IBD. Z. multiflora was administered (400, 600, 900 p.p.m.) through drinking water to IBD mice induced by intrarectal administration of acetic acid. Prednisolone was used as the standard drug for comparison. Biochemical, macroscopic and microscopic examinations of colon were performed. Biochemical evaluation of inflamed colon was done using assay of myeloperoxidase (MPO) activity and thiobarbituric acid reactive substances (TBARS) concentration as indicators of free radical activity and cell lipid peroxidation. The activity of MPO and lipid peroxidation products (TBARS) increased in acetic acid-treated groups while recovered by pretreatment of animals with Z. multiflora (400-900 p.p.m.) and prednisolone. Z. multiflora (600 and 900 p.p.m.) and prednisolone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the acetic acid-treated group. The beneficial effect of Z. multiflora (900 p.p.m.) was comparable with that of prednisolone. The antioxidant, antimicrobial and anti-inflammatory potentials of Z. multiflora might be the mechanisms by which this herbal extract protects animals against experimentally induced IBD. Proper clinical investigation should be carried out to confirm the activity in human.

Keywords: inflammatory bowel disease; antioxidant; cells lipid peroxidation; myeloperoxidase; rat; Zataria.
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