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eCAM Advance Access published online on July 26, 2006
eCAM, doi:10.1093/ecam/nel049
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© 2006 The Author(s).
Received February 1, 2006
Accepted June 18, 2006

Original Article

Housing in Pyramid Counteracts Neuroendocrine and Oxidative Stress Caused by Chronic Restraint in Rats

M. Surekha Bhat 1 *, Guruprasad Rao 1, K. Dilip Murthy 2, and P. Gopalakrishna Bhat 3

1 Department of Biochemistry, Melaka Manipal Medical College, Manipal 576104, India
2 Department of Physiology, Melaka Manipal Medical College, Manipal 576104, India
3 Department of Biochemistry, Kasturba Medical College, Manipal 576104, India

* To whom correspondence should be addressed.
M. Surekha Bhat, E-mail: surekha.bhat{at}manipal.edu; surekhakka@yahoo.com


  Abstract

The space within the great pyramid and its smaller replicas is believed to have an antistress effect. Research has shown that the energy field within the pyramid can protect the hippocampal neurons of mice from stress-induced atrophy and also reduce neuroendocrine stress, oxidative stress and increase antioxidant defence in rats. In this study, we have, for the first time, attempted to study the antistress effects of pyramid exposure on the status of cortisol level, oxidative damage and antioxidant status in rats during chronic restraint stress. Adult female Wistar rats were divided into four groups as follows: normal controls (NC) housed in home cage and left in the laboratory; restrained rats (with three subgroups) subject to chronic restraint stress by placing in a wire mesh restrainer for 6 h per day for 14 days, the restrained controls (RC) having their restrainers kept in the laboratory; restrained pyramid rats (RP) being kept in the pyramid; and restrained square box rats (RS) in the square box during the period of restraint stress everyday. Erythrocyte malondialdehyde (MDA) and plasma cortisol levels were significantly increased and erythrocyte-reduced glutathione (GSH) levels, erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were significantly decreased in RC and RS rats as compared to NC. However, these parameters were maintained to near normal levels in RP rats which showed significantly decreased erythrocyte MDA and plasma cortisol and significantly increased erythrocyte GSH levels, erythrocyte GSH-Px and SOD activities when compared with RS rats. The results showed that housing in pyramid counteracts neuroendocrine and oxidative stress caused by chronic restraint in rats.

Keywords: chronic restraint; glutathione; glutathione peroxidase; pyramid model; superoxide dismutase; TBARS.
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