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eCAM Advance Access published online on July 5, 2006
eCAM, doi:10.1093/ecam/nel047
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© 2006 The Author(s).
Received June 11, 2006
Accepted June 12, 2006

Review

Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Tumor Immunity, Autoimmunity and Alloreactive Immunity (III)

Aristo Vojdani 1 * and Jonathan Erde 1

1 Immunosciences Lab., Inc., 8693 Wilshire Boulevard, Suite 200, Beverly Hills, CA 90211, USA

* To whom correspondence should be addressed.
Aristo Vojdani, E-mail: immunsci{at}ix.netcom


  Abstract

Regulatory T (Treg) cells are the major arbiter of immune responses, mediating actions through the suppression of inflammatory and destructive immune reactions. Inappropriate Treg cell frequency or functionality potentiates the pathogenesis of myriad diseases with ranging magnitudes of severity. Lack of suppressive capability hinders restraint on immune responses involved in autoimmunity and alloreactivity, while excessive suppressive capacity effectively blocks processes necessary for tumor destruction. Although the etiology of dysfunctional Treg cell populations is under debate, the ramifications, and their mechanisms, are increasingly brought to light in the medical community. Methods that compensate for aberrant immune regulation may not address the underlying complications; however, they hold promise for the alleviation of debilitating immune system-related disorders. The dominant immunoregulatory nature of Treg cells, coupled with recent mechanistic knowledge of natural immunomodulatory compounds, highlights the importance of Treg cells to practitioners and researchers of complementary and alternative medicine (CAM).

Keywords: alloreactive immunity; autoimmunity; CAM; Cancer; regulatory T Cells; Treg.
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