eCAM Advance Access published online on May 2, 2006
eCAM, doi:10.1093/ecam/nel016
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1 Department of Scienze Morfologico-Biomediche, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
* To whom correspondence should be addressed. A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the simile, the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional simile rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.
Received December 5, 2005
Accepted March 16, 2006
Lecture Series
Immunology and Homeopathy. 3. Experimental Studies on Animal Models
Paolo Bellavite 1 *,
Riccardo Ortolani 2,
and
Anita Conforti 3
2 Association for Integrative Medicine "Giovanni Scolaro", University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
3 Department of Medicina e Sanità Pubblica, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
Paolo Bellavite, E-mail: paolo.bellavite{at}univr.it
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