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eCAM Advance Access published online on May 3, 2006
eCAM, doi:10.1093/ecam/nel006
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© The Author (2006). Published by Oxford University Press. All rights reserved.
Received November 10, 2005
Accepted February 10, 2006

Original Article

Bioactive Constituents of Brazilian Red Propolis

Boryana Trusheva 1, Milena Popova 1, Vassya Bankova 1 *, Svetlana Simova 1, Maria Cristina Marcucci 2, Patricia Laguna Miorin 2, Flavia da Rocha Pasin 2, and Iva Tsvetkova 3

1 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
2 Faculdade de Farmacia, Universidade Bandeirante de Sao Paulo, Rua Maria Candida, 1813, Vila Guilherme, Campus MC, 02071-013 Sao Paulo, SP Brazil
3 Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Building 26, 1113 Sofia, Bulgaria

* To whom correspondence should be addressed.
Vassya Bankova, E-mail: bankova{at}orgchm.bas.bg


  Abstract

In a new propolis type, red Brazilian propolis, 14 compounds were identified (six of them new for propolis), among them simple phenolics, triterepenoids, isoflavonoids, prenylated benzophenones and a naphthoquinone epoxide (isolated for the first time from a natural source). Three of the major components demonstrated significant antimicrobial activity, and two (obtained as inseparable mixture) possessed radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).

Keywords: antibacterial activity; chemical constituents; propolis; radical scavenging activity.
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