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eCAM Advance Access published online on January 30, 2006
eCAM, doi:10.1093/ecam/nek008
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© The Author (2006). Published by Oxford University Press. All rights reserved.
Received August 12, 2005
Accepted December 26, 2005

Original Article

Bioactive Components of the Traditionally used Mushroom Podaxis pistillaris

M. A. A. Al-Fatimi 1, W.-D. Jülich 2, R. Jansen 3, and U. Lindequist 2 *

1 Department of Pharmacognosy, Aden University, Aden, Yemen
2 Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, F.-L.-Jahn-Strasse 15, D-17487 Greifswald, Germany
3 German Research Center for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany

* To whom correspondence should be addressed.
U. Lindequist, E-mail: lindequi{at}uni-greifswald.de


  Abstract

In the course of an ethnobotanical study on fungi used in Yemeni ethnomedicine the fungus Podaxis pistillaris (Podaxales, Podaxaceae, Basidiomycetes) was found to exhibit antibacterial activity against Staphylococcus aureus, Micrococcus flavus, Bacillus subtilis, Proteus mirabilis, Serratia marcescens and Escherichia coli. In the culture medium of P. pistillaris three epidithiodiketopiperazines were identified by activity-guided isolation. Based on spectral data (NMR, ESI-MS and DCI-MS) their identity was established as epicorazine A (1), epicorazine B (2) and epicorazine C (3, antibiotic F 3822), which have not been reported as constituents of P. pistillaris previously. It is assumed that the identified compounds contribute to the antibacterial activity of the extract.

Keywords: Epicorazines; antibacterial; cytotoxic; Yemen.
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