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eCAM Advance Access published online on November 8, 2005
eCAM, doi:10.1093/ecam/neh127
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© The Author (2005). Published by Oxford University Press. All rights reserved.
Received June 10, 2004
Accepted September 12, 2005

Review

Post-Traumatic Stress Disorder: Evidence-Based Research for the Third Millennium

Javier Iribarren 1, Paolo Prolo 2, Negoita Neagos 3, and Francesco Chiappelli 2*

1 David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
2 UCLA School of Dentistry, Los Angeles, CA, USA; Psychoneuroimmunology Group, Inc., Los Angeles, CA, USA
3 Psychoneuroimmunology Group, Inc., Los Angeles, CA, USA

* To whom correspondence should be addressed.
Francesco Chiappelli, E-mail: chiappelli{at}dent.ucla.edu


  Abstract

The stress that results from traumatic events precipitates a spectrum of psycho-emotional and physiopathological outcomes. Post-traumatic stress disorder (PTSD) is a psychiatric disorder that results from the experience or witnessing of traumatic or life-threatening events. PTSD has profound psychobiological correlates, which can impair the person's daily life and be life threatening. In light of current events (e.g. extended combat, terrorism, exposure to certain environmental toxins), a sharp rise in patients with PTSD diagnosis is expected in the next decade. PTSD is a serious public health concern, which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention. We review the current knowledge of PTSD and introduce the role of allostasis as a new perspective in fundamental PTSD research. We discuss the domain of evidence-based research in medicine, particularly in the context of complementary medical intervention for patients with PTSD. We present arguments in support of the notion that the future of clinical and translational research in PTSD lies in the systematic evaluation of the research evidence in treatment intervention in order to insure the most effective and efficacious treatment for the benefit of the patient.

Keywords: post-traumatic stress syndrome; allostasis; evidence-based research; complementary medicine.
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