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eCAM Advance Access published online on February 9, 2005

eCAM, doi:10.1093/ecam/neh065
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© The Author (2005). Published by Oxford University Press. All rights reserved.
Received September 10, 2004
Revised December 10, 2004
Accepted January 11, 2005

Review

Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties

Belal Naser 1*, Cornelia Bodinet 1, Martin Tegtmeier 1, and Ulrike Lindequist 2

1 Schaper & Brümmer GmbH & Co. KG, Salzgitter, Germany
2 Institute for Pharmacy, Ernst-Moritz-Arndt University, Greifswald, Germany

* To whom correspondence should be addressed.
Belal Naser, E-mail: belal.naser{at}schaper-bruemmer.de


   Abstract

Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections.

Keywords: Thuja occidentalis; common cold; Thujone; Esberitox.
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