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eCAM Advance Access published online on August 4, 2004
eCAM, doi:10.1093/ecam/neh020
Copyright © 2004 by the Oxford University Press.
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Received December 5, 2003
Accepted March 26, 2004

Brief Communication

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome

Xin Q Wang 1, Takashi Takahashi 1, Shi-jie Zhu 1, Junji Moriya 1, Seiichiro Saegusa 1, Jun'ichi Yamakawa 1, Kazuya Kusaka 1, Tohru Itoh 1, Tsugiyasu Kanda 1*

1 Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan

* To whom correspondence should be addressed. E-mail: kandat{at}kanazawa-med.ac.jp.


  Abstract

We aimed to evaluate the effect of a Japanese herbal medicine, Hochu-ekki-to (TJ-41), on daily activity in a murine model of chronic fatigue syndrome (CFS). CFS was induced by repeated injection of Brucella abortus (BA) antigen every 2 weeks. TJ-41 was orally administered to mice in a dose of 500 mg/kg/day for 1 week before injecting BA and for 4 weeks thereafter. We evaluated daily running activity in mice receiving TJ-41 as compared with that in untreated mice. Survival of both mouse groups was also monitored during the observation period. Body weight (BW), spleen weight (SW), SW/BW ratio and expression levels of interleukin-10 (IL-10) mRNA in spleen were determined in both groups at the time of sacrifice. The daily activity was significantly higher in the treated group than in the control. Two mice in the untreated group died 2 days after the second injection of BA, whereas no mice in the group treated with TJ-41 died. The SW and SW/BW ratio were significantly lower in the treated mice than in the control. Suppressed IL-10 mRNA levels were observed in the spleens of the mice treated with TJ-41. Our data suggest that Hochu-ekki-to might possess an inhibitory effect on the marked decrease in running activity following BA injection.

Keywords: Hochu-ekki-to; herbal medicine; daily activity; chronic fatigue syndrome.
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