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eCAM Advance Access originally published online on March 25, 2007
eCAM 2008 5(2):165-171; doi:10.1093/ecam/nem014
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cytoprotective Activity of Glycyrrhizae radix Extract Against Arsenite-induced Cytotoxicity

Sang Chan Kim1,2, Sook Jahr Park1, Jong Rok Lee1,2, Jung Cheol Seo1,2, Chae Ha Yang1,2 and Sung Hui Byun1

1College of Oriental Medicine and 2Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University, 165 Sang-dong, Suseong-gu, Daegu 706-060, Korea

Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated the effect of licorice on arsenite (As)-induced cytotoxicity in H4IIE cells, a rat hepatocyte-derived cell line. Cell viability was significantly diminished in As-treated H4IIE cells in a time and concentration-dependent manner. Furthermore, results from flow cytometric assay and DNA laddering in H4IIE cells showed that As treatment induced apoptotic cell death by activating caspase-3. Licorice (0.1 and 1.0 mg ml–1) treatment significantly inhibited cell death and the activity of caspase-3 in response to As exposure. These results demonstrate that licorice induced a cytoprotective effect against As-induced cell death by inhibition of caspase-3.

Keywords: apoptosis – arsenite – cytotoxicity – licorice

For reprints and all correspondence: Sung Hui Byun, College of Oriental Medicine, Daegu Haany University, 165 Sang-dong, Suseong-gu, Daegu 706-060, South Korea. Tel: +82-53-770-2244; Fax: +82-53-768-6340; E-mail: shbyun{at}dhu.ac.kr

Received May 9, 2006; accepted January 16, 2007


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