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eCAM Advance Access originally published online on December 12, 2006
eCAM 2007 4(3):355-359; doi:10.1093/ecam/nel102
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Indigofera suffruticosa: An Alternative Anticancer Therapy

Jeymesson Raphael Cardoso Vieira1, Ivone Antônia de Souza2, Silene Carneiro do Nascimento2 and Sônia Pereira Leite3

1Universidade Federal de Pernambuco/Departamento de Patologia do Centro de Ciências da Saúde Recife-PE Recife-PE, Brazil, 2Universidade Federal de Pernambuco/Departamento de Antibióticos do Centro de Ciências Biológicas Recife-PE, Brazil and 3Universidade Federal de Pernambuco/Departamento de Histologia e Embriologia do Centro de Ciências Biológicas Recife-PE, Brazil

Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves of I. suffruticosa obtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg–1 (intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves of I. suffruticosa may be used as an alternative anticancer agent.

Keywords: antitumor – aqueous extract – cytotoxicity – Indigofera suffruticosa – toxicity

For reprints and all correspondence: Sônia Pereira Leite, Laboratório de Cultura de Células II, Departamento de Histologia e Embriologia do Centro de Ciências Biológica da Universidade Federal de Pernambuco (UFPE), Cidade Universitária, Recife, 50.670-420, Pernambuco, Brazil. Tel: +55-81-21268515; Fax: +55-81-21268516; E-mail: spl{at}ufpe.br

Received July 5, 2006; accepted October 30, 2006


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