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eCAM Advance Access originally published online on November 24, 2006
eCAM 2007 4(2):203-207; doi:10.1093/ecam/nel088
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Nourishing Yin and Promoting Blood Circulation of TCM to Treat Hemorheologic Disorder Induced by Diabetes Mellitus in Rats

Rong Xia1, Ping Huang2 and Guo-ming Shao3

1Department of Basic Medicine, Zhejiang Chinese Medical University Binjiang, Hangzhou 310053, Zhejiang Province, China, 2Department of Endocrinology, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China and 3Department of Laboratory, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China

Diabetes mellitus, DM, is commonly accompanied with various stages of hemorheologic disturbances that are the main causes of the development of chronic DM. In this study, simple Chinese material medica [yang-yin jiang-tang preparation (YYJT)] was given to alloxan-induced DM rats and analyzed to compare the changes of fasting blood glucose (FBG), fasting insulin (FINS), hemorheologic parameters and insulin-like growth factor II (IGF-II) before and after administration. The results suggested that YYJT can significantly downregulate FBG (P < 0.005), improve insulin resistance and beta-cell secretion (P < 0.05), decrease whole blood viscosity at low and high shear rates, gathering of blood index test (GIT) and fibrinogen (FIB) (P < 0.05), and enlarge the function of IGF-II (P < 0.05). We concluded that YYJT could prevent and treat hemorheologic disorder in DM rats by means of reducing glucose, improving insulin resistance and elevating IGF-II.

Keywords: Chinese material medica – diabetes mellitus rat – hemorheology – insulin resistance – insulin secretion – insulin-like growth factor II

For reprints and all correspondence: Rong Xia, MD, PhD, Department of Basic Medicine, Zhejiang Chinese Medical University, 548 Binwenlu, Hangzhou 310053, Zhejiang Province, China. Tel: +86-571-86613773; Fax: +86-571-86613610; E-mail: xiarong248{at}hotmail.com

Received February 1, 2006; accepted October 12, 2006


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