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eCAM Advance Access originally published online on June 24, 2006
eCAM 2006 3(4):459-467; doi:10.1093/ecam/nel030
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© The Author (2006). Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Stimulating Effect of Japanese Herbal (Kampo) Medicine, Hochuekkito on Upper Respiratory Mucosal Immune System

H. Kiyohara1,2, T. Nagai1,2, K. Munakata1,2, K. Nonaka1, T. Hanawa2, S. J. Kim2 and H. Yamada1,2

1 The Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University Tokyo, Japan, and 2 Oriental Medicine Research Center, The Kitasato Institute Tokyo, Japan

Japanese herbal (Kampo) medicine, Hochuekkito (Bu-Zhong-Yi-Qi-Tang in Chinese, TJ-41) and Juzentaihoto (Shi-Quan-Da-Bu-Tang in Chinese, TJ-48) are well-known Kampo formulas used as tonic. Although these medicines have separately been applied to the patients clinically depending on their symptoms, the differences of the pharmacological activities for these medicines have not been fully understood. TJ-48 and TJ-41 were compared for their effects on antibody response in upper respiratory mucosal immune system in vivo. Oral administration of TJ-41 (100 mg kg–1 per day) to early aged BALB/c mice, which were nasally sensitized with influenza hemagglutinin vaccine, significantly enhanced influenza virus-specific IgA and IgG antibody titers in nasal cavity and sera, respectively. However, oral administration of TJ-48 (100 mg kg–1 per day) failed to show the enhancing activity. TJ-41 increased not only influenza virus-specific IgA antibody titer but also total IgA antibody titer in nasal cavity. The stimulating activity of TJ-41 disappeared after treatment with methotrexate. The present study strongly suggests that TJ-41 can stimulate the mucosal immune system of upper respiratory tract, and results in enhancement of antigen-specific antibody response in upper respiratory mucosal and systemic immune systems.

Keywords: Hochuekkito – influenza virus – Japanese herbal (Kampo) medicine – mucosal immune system of upper respiratory tract – specific antibody response

For reprints and all correspondence: Haruki Yamada, The Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Tel: +81-3-5791-6364; Fax: +81-3-3445-1351; E-mail: yamada{at}lisci.kitasato-u.ac.jp


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