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eCAM Advance Access originally published online on July 5, 2005
eCAM 2005 2(3):375-381; doi:10.1093/ecam/neh099
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Alcoholic Stem Extract of Coscinium fenestratum Regulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats

I. S. R. Punitha1, K. Rajendran1, Arun Shirwaikar2 and Annie Shirwaikar1,*

1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences Manipal 576104, India, and 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences Manipal 576104, India

Alcoholic extract of the stems of Coscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration of C. fenestratum stem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity of C. fenestratum.

Keywords: carbohydrate metabolism – Coscinium fenestratum – enzymatic antioxidants – nonenzymatic antioxidants – streptozotocin–nicotinamide induced diabetes

*For reprints and all correspondence: Dr Annie Shirwaikar, Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka 576104, India. Tel: 191 820 2571201 22430; Fax: 191 820 2571998; E-mail: annieshirwaikar{at}yahoo.com


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