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eCAM Advance Access originally published online on July 20, 2005
eCAM 2005 2(3):277-283; doi:10.1093/ecam/neh100
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Review

CAM and Cell Fate Targeting: Molecular and Energetic Insights into Cell Growth and Differentiation

Carlo Ventura

Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems and Institute of Cardiology, S. Orsola—Malpighi Hospital, University of Bologna 40138 Bologna, Italy

Evidence-based medicine is switching from the analysis of single diseases at a time toward an integrated assessment of a diseased person. Complementary and alternative medicine (CAM) offers multiple holistic approaches, including osteopathy, homeopathy, chiropractic, acupuncture, herbal and energy medicine and meditation, all potentially impacting on major human diseases. It is now becoming evident that acupuncture can modify the expression of different endorphin genes and the expression of genes encoding for crucial transcription factors in cellular homeostasis. Extremely low frequency magnetic fields have been found to prime the commitment to a myocardial lineage in mouse embryonic stem cells, suggesting that magnetic energy may direct stem cell differentiation into specific cellular phenotypes without the aid of gene transfer technologies. This finding may pave the way to novel approaches in tissue engineering and regeneration. Different ginseng extracts have been shown to modulate growth and differentiation in pluripotent cells and to exert wound-healing and antitumor effects through opposing activities on the vascular system, prompting the hypothesis that ancient compounds may be the target for new logics in cell therapy. These observations and the subtle entanglement among different CAM systems suggest that CAM modalities may deeply affect both the signaling and transcriptional level of cellular homeostasis. Such a perception holds promises for a new era in CAM, prompting reproducible documentation of biological responses to CAM-related strategies and compounds. To this end, functional genomics and proteomics and the comprehension of the cell signaling networks may substantially contribute to the development of a molecular evidence–based CAM.

Keywords: acupuncture – differentiation – energy medicine – gene expression – stem cells

For reprints and all correspondence: Carlo Ventura, Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems and S. Orsola—Malpighi Hospital, Institute of Cardiology, Pavilion 21, Via Massarenti N. 9, University of Bologna, Bologna 40138, Italy. Tel: +39-051-6363605, 340339; Fax: +39-051-344859; E-mail: cvent{at}libero.it, carlo.ventura{at}unibo.it


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