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eCAM 2005 2(2):217-221; doi:10.1093/ecam/neh095
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© The Author (2005). Published by Oxford University Press. All rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

BHUx: A Patent Polyherbal Formulation to Prevent Atherosclerosis

Yamini B. Tripathi1,*, Birendra K. Singh1, Ravi S. Pandey1 and Mohan Kumar2

1Department of Medicinal Chemistry, Banaras Hindu University Varanasi-221005, India, and 2Pathology, Institute of Medical Sciences, Banaras Hindu University Varanasi-221005, India

Ayurvedic medicine is a time-tested system of medicine which has been in clinical use for centuries in India. Being a time-tested system, it has an edge over other existing systems of health management, especially for dealing with chronic disorders such as coronary artery disease, which is of a complex multi-etiological nature. Recently, we have shown that BHUx, a patented polyherbal formulation consisting of the aqueous fraction of five medicinal plants of the ayurvedic system, has significant anti-inflammatory properties through inhibition of cyclooxygenase-2 and lipoxygenase-15. Here we have investigated its effect on diet-induced atherosclerosis in albino rabbits. BHUx was given orally for 3 months to rabbits pre-treated with an atherogenic diet for 3 months. After 6 months, the dorsal aorta was processed for histological studies for calcium and collagen content. The results demonstrated a remarkable reduction in intimal thickening in the treated animals. In addition, there was less calcification at the intima–medial interface and increased intensity of collagen cap on the surface along with an increase in survival, compared with the sham control. We suggest that BHUx is a potent, multi-factorial formulation against atherosclerosis.

Keywords: atherosclerosis – polyherbal – ayurveda – diet-induced atherosclerosis

*For reprints and all correspondence: Dr Yamini B. Tripathi, Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India. Tel: +91-542-2366577, 2369659; Fax: +91-542-2366566; E-mail: yaminiok{at}yahoo.com, yaminitripathi{at}epatra.com


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