Skip Navigation


eCAM Advance Access originally published online on August 4, 2004
eCAM 2004 1(2):203-206; doi:10.1093/ecam/neh020
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
1/2/203    most recent
neh020v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Wang, X. Q
Right arrow Articles by Kanda, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, X. Q
Right arrow Articles by Kanda, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2004, the authors Evidenced-based Complementary and Alternative Medicine, Vol. 1, Issue 2 © Oxford University Press 2004; all rights reserved. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated.

Brief Communication

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome

Xin Q Wang, Takashi Takahashi, Shi-jie Zhu, Junji Moriya, Seiichiro Saegusa, Jun'ichi Yamakawa, Kazuya Kusaka, Tohru Itoh and Tsugiyasu Kanda*

Department of General Medicine, Kanazawa Medical University Ishikawa, Japan

We aimed to evaluate the effect of a Japanese herbal medicine, Hochu-ekki-to (TJ-41), on daily activity in a murine model of chronic fatigue syndrome (CFS). CFS was induced by repeated injection of Brucella abortus (BA) antigen every 2 weeks. TJ-41 was orally administered to mice in a dose of 500 mg/kg/day for 1 week before injecting BA and for 4 weeks thereafter. We evaluated daily running activity in mice receiving TJ-41 as compared with that in untreated mice. Survival of both mouse groups was also monitored during the observation period. Body weight (BW), spleen weight (SW), SW/ BW ratio and expression levels of interleukin-10 (IL-10) mRNA in spleen were determined in both groups at the time of sacrifice. The daily activity was significantly higher in the treated group than in the control. Two mice in the untreated group died 2 days after the second injection of BA, whereas no mice in the group treated with TJ-41 died. The SW and SW/BW ratio were significantly lower in the treated mice than in the control. Suppressed IL-10 mRNA levels were observed in the spleens of the mice treated with TJ-41. Our data suggest that Hochu-ekki-to might possess an inhibitory effect on the marked decrease in running activity following BA injection.

Keywords: Hochu-ekki-to – herbal medicine – daily activity – chronic fatigue syndrome

*For reprints and all correspondence: Tsugiyasu Kanda, Department of General Medicine, Kanazawa Medical University, 1–1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan. Fax: +81-76-286-2702. E-mail: kandat{at}kanazawa-med.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
J.-i. Yamakawa, J. Moriya, T. Takahashi, A. Ishige, Y. Motoo, F. Yoshizaki, and T. Kanda
A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
Evid. Based Complement. Altern. Med., November 14, 2007; (2007) nem153v1.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
E. L. Cooper
Complementary and Alternative Medicine: Challenge to eCAM.
Evid. Based Complement. Altern. Med., March 1, 2006; 3(1): 1 - 2.
[Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
T. Takahashi, F. Yu, S.-j. Zhu, J. Moriya, H. Sumino, S. Morimoto, N. Yamaguchi, and T. Kanda
Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.
Evid. Based Complement. Altern. Med., March 1, 2006; 3(1): 109 - 115.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.