eCAM 2005 2(4):429-439; doi:10.1093/ecam/neh139
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The Systemic Theory of Living Systems. Part IV: Systemic MedicineThe Praxis
José A. Olalde Rangel*,
Meyer Magarici,
Francis Amendola and
Oswaldo del Castillo
Adaptogenic Medical Centers Calle del Arenal c/c Luis de Camoes, La Trinidad, Caracas 1080, Venezuela
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Abstract
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This fourth lecture illustrates the praxis and results of Systemic
Medicine (SM) in various therapeutic applications. SM's success
has made it popular throughout Venezuela and Puerto Rico. The
treatment of over 300 000 patients by 150 orthodox MD's, trained
and qualified in SM, in 35 medical establishments with above
average results corroborate its effectiveness as an
eCAM in
chronic degenerative diseases. Herein we provide a synopsis
of results obtained in four such pathologiesthe journal's
necessary space restrictions somewhat limiting contentas
well as clinical and photographic evidence. The validity of
any medical theory is substantiated by its degree of effectivity
and success. The workability of evidence-based SM corroborates
Systemic Theory's transcendence.
Keywords: adaptogen – diabetes – negentropy – polycystic ovarian syndrome – psoriasis – synergetics – systemic medicine – systemic theory – varicose ulcer
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Past and Present Naturalists ... Tomorrow's Systemics?
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Recent past and even present successful naturalists and phytotherapeutic
practitioners share a long and honorable tradition of knowledge
and pride in the cure of illnesses, which goes back to written
history and beyond. These qualities have been substantiated
by the success of Chinese (
1,
2), Kampo (
3,
4), Ayurvedic (
5),
Chumash (
6) or Mayan (
7) among many other traditional medicines.
These traditional medicines have demonstrated that every
culture is capable of understanding and "inventing" the meaning
of disease and its cure, even when it is different from our
modern medical views (
7). The variability and extent
of cultures to provide answerstraditional medicinesto
pathologies are embedded in the curiosity and observational
capabilities of the human race. There are collective factors
such as a background of extensive family in traditional
medicine (
8) which play an important role in the transmission
and survival of medicinal plant knowledge among ethnic groups.
A potential issue, though, is the possible curtailment of the
wisdomand therapiesof traditional medicines within
geographical and ethnic boundaries. In any case, the amount
of plants, potential formulations or properties are a massive
concern for any given individual caregiver or group to understand,
store and transmit.
But, perhaps, it may be possible to set up a system or periodic table where plants and other natural remedies could, according to their properties, be arranged to produce specific formulae that provide well-being for a given pathology. Some exceptional individuals seem to have come by this ability. One of these gifted health care practitioners was Maurice Messegue, whom Mistinguet and Konrad Adenauramong his famous patientsswore that only he could treat their illnesses. More recently, both, Dr. Rusudan Lomidze, using the Georgian Kohlkian traditional medicine, and Lonrig Dangar, a Tibetan physician who applied the rich Tibetan traditional medicine have also obtained significant success. These gifted individuals have shown that traditional medicine is a successful medicine. But a question still hangs in the air? Might a theory be devised by which regular practitioners, health care specialists devoid of the naturalists' extensive background, might formulate natural organic therapeutic protocols?
The Systemic Theory is set forth herein to provide an answer to this crucial question.
Systemic Theory postulates that Health (H) is directly proportional to the integrity of a living system's Energy (E), Bio-Intelligence (I) and Organization (O) as shown in Fig. 1. Systemic Theory also establishes a common denominator to all sickness (Fig. 2) and ascertains the cause of all disease to be an entropy increase: disorder augmenting within the biologically open system, stemming from energo-informational and organizational impacts, either of external or internal nature (911). Therapeutics should then include a negentropy supply to enhance the system's energywork capacity (E), its informational potential (I) intelligence, and finally structure and functional organization (O).

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Figure 1 The Health Triangle is born out of the system's Intelligence that generates Organization and produces Energy.
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Figure 2 Entropy increase brought upon by physical, chemical, biological and emotional impacts bring about the system's collapse.
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Systemic Medicine's (SM) treatment strategy is based on identifying
and prescribing superior herbstonic or adaptogenicor
any nutraceuticals or medicine with potential to strengthen
E, I, O by providing energo, informational and organizational
aid to the overall network of intelligent cells and cell systems
that constitute the body. The main premise proposes that when
all three factors are brought back to ideal levels patients'
conditions begin recovery to normal health.
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Evaluating the Praxis of Systemic Theory: Systemic Medicine
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To corroborate the validity of the Systemic approach, we examined
the results of its clinical application in chronic degenerative
diseases (CDD) through retrospective studies carried out at
the Adaptogenic Medical Centres located in Venezuela and Puerto
Rico. Also included in the studies, were patients attending
the following public hospitals (in Venezuela): Dr Domingo Luciani
Hospital, Caracas; Dr Raúl Leoni Hospital, San Félix;
and the Rehabilation Center of the Venezuelan Social Security
Institute, Caracas. Three parameters were compared, ante and
post-SM treatment, and these factors were as follows: Clinical
results; Quality of Life (QoL) (
12); and Tolerance to treatment.
All patients included in these studies had formerly received
orthodox treatments without any success in preventing disease
progression. Thus, SM became the first choice treatment or even
the unique alternative therapy. The complete studies of the
pathologies included in this lecture as well as other CDD studies
may be found at
www.adaptogeno.com.
Outcomes of these as well as other studies have been presented at several scientific events such as 8th International Electrotherapy Congress in Nanning, China, September 2004; First International Neurobiotelekom Congress, in Saint Petersburg, Russian Federation, December 2004; First International Systemic Medicine Congress in Caracas, Venezuela, January 2005; Latin American Center Symposium on Environment and Health: Exploring Natural Products, UCLA, April 2005; First International Congress on Complementary and Alternative Treatments in Cancer, in Madrid, Spain, May 2005; and finally at the Science Information and Spirit Seminar in St Petersburg, Russian Federation, June 2005.
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Clinical Study I: Diabetic Foot. Summary of Outcomes and Comparative Photographic Evidence
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The therapeutic outcome is examined in 110 patients with diverse
degrees of diabetic foot (
13) through a retrospective, multicenter,
descriptive 2 year long study (
14). This treatment clinically
improved 80.9% of the total diabetic foot population studied
(
P < 0.00001). SM prevented amputation in 40 patients (80%)
of all cases diagnosed for surgical removal of limbs (50 patients).
There was a significant improvement in QoL86.36% of all
diabetic foot cases (
P < 0.00001). Tolerance to treatment
was found to be excellent (
Table 1). Results (
Fig. 3) suggest
that SM is the best therapeutic option for patients affected
with diabetic foot.

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Figure 3 Photographic evidence of diabetic foot remissions, including length of treatment between photos.
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Clinical Study II: Severe Psoriasis. Resumé of Results and Illustrative Before and After Case Contrast
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The outcome on the effects of SM in 123 patients with severe
psoriasis was examined through a retrospective, multicenter,
descriptive 2 year long study (
15). Improvement in clinical
remission was observed in 77.23% of patients (
P < 0.00001).
Almost two-thirds of all patients achieved clinical improvement
in <46 days. QoL improvement is observed in 82.93% of patients
(
P < 0.00001). This therapeutic formula was particularly
effective in severe varieties of this pathology. Treatment tolerance
was excellent (
Table 2). Results confirm a high remission rate,
without side effects, in patients treated with SM. This suggests
that SM is a superior therapeutic tool (
Fig. 4).

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Figure 4 Photographic evidence of severe psoriasis remissions, including length of treatment between photos.
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Clinical Study III: Varicose Ulcer. Synopsis of Results, Before and After Photo Comparison
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SM protocol was evaluated in 129 patients with chronic varicose
ulcers through a retrospective, multicenter, descriptive 2 year
long study (
16). This treatment improved ulcers in 79% of the
population. A remission of 21% of all patients was achieved
in only 2 months. Systemic treatment also significantly improved
the most frequent symptoms (cramps 71.4%, pain 78% and edema
88.7%) (
Table 3). About 105 patients had QoL improvement. Some
examples of results are seen in
Fig. 5. The tolerance was excellent.

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Figure 5 Photographic evidence of varicose ulcer remissions, including length of treatment between photos.
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Clinical Study IV: Polycystic Ovarian Syndrome. Results, Before and After Graphic Differences
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Thirty-five patients with polycystic ovarian syndrome (PCOS)
were included in a retrospective, multicenter, descriptive 2
year long study to evaluate their response to a systemic protocol
designed to improve their condition and/or obtain remission
to the aforementioned pathology (
17). SM improved pelvic pain
in all 20 symptomatic patients (
P < 0.00001); menstrual disorders
(amenorrhea, dysmenorrhea, menorrhagia, menometrorrhagia, oligomenorrhea)
in all 22 symptomatic patients (
P < 0.00001); asthenia and
cephalea in all 17 symptomatic patients (
P < 0.0001); as
well as acne and hirsutism in 8 out of 9 (89%) symptomatic patients
(
P < 0.0133). Pelvic ecosonograms revealed that 29 patients
(82.8%) experienced a total disappearance of cysts, whereas
6 patients (17.2%) showed decrease in cyst size (
Table 4). QoL
improved in 100% of patients (
P < 0.0001). Tolerance to treatment
was outstanding (100%). To conclude, evidence-based results
in PCOS treatment, with SM, suggest a remarkable CAM therapy
(
Fig. 6).
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E, I, O Classification of Superior Medicines
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Adaptogens, tonics and nutraceuticals, in SM, are classified
according to their E, I, O potential, i.e. as Energoceuticals,
Infoceuticals and Organoceuticals. Examples of these by category
are in
Table 5.
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Systemic Protocol for Diabetic Foot
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A complete description of each systemic protocol exceeds the
scope of this article; however, a summarized example for diabetic
foot is illustrated below.
E
:Leuzea carthamoides
Ecdysone phytosteroids activate enzyme synthesis pro-cellular ATP synthesis (27,30).
I
:Ganoderma lucidum
Ganoderan B and dozens of other polysaccharides and beta-glucans stimulate neuroendocrine intelligence and cell immunity (46,47,105,106). Glycans' path for immune enhancement is not certain but Chihara et al. (107) have proposed a likely model modified by Kidd (108) (Fig. 7).
O
Gingko biloba
Flavonolglycosides, bioflavonoids, ginkgolides and bilobalides increase vascular flow (77,78).
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The Healing Law of Synergetics
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Healing potential, negentropy gain, is directly proportional
to synergetic contribution (SC) (
11). SC is exponentially proportional
to the number of contributive active principles (
n) in a formulaergo
in a protocol. The Healing Law of Synergetics is thus derived:
Remission in chronic degenerative diseases,
S >> 0, depends
on (
n2 +
n)/2.
Figure 8 demonstrates the exponential number
of SC as
n increases.

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Figure 8 The Law of Synergetics is depicted by an exponential curve that provides a measure of the healing potential of the contributive active principles.
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This law is valid as long as genetic functioning is minimally
intact. The greater the SC is, the greater the probability of
recovery. Thus all therapeutic formulations should in consequence
include as many E, I, O nutraceuticals as possible.
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Analysis
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There is probably greater potential in developing formulations
of synergetic natural supplements than in synthetics for CDD.
The potential ... to introduce these compounds in the
treatment of human diseases in order to raise public awareness
on the richness and diversity of natural products that could
be carefully harvested for the benefit of mankind as
Cooper points out, is enormous (
109).
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Conclusion
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Based on the Law of Synergetics future therapeutics should consist
of thousands of potentially active E, I, O active principles
from all organic sources available. This opens up a huge potentialhitherto
ignoredfor humanity.
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Footnotes |
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*For reprints and all correspondence: José A. Olalde Rangel, Adaptogenic Medical Centers, Calle del Arenal c/c Luis de Camoes, La Trinidad, Caracas 1080, Venezuela. E-mail:
corpgov2004{at}yahoo.com
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Acknowledgments
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We express sincere appreciation and gratitude to Professor Edwin
L. Cooper for his invaluable support in making possible the
four publications of the Systemic Theory and Praxis.
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Received September 29, 2005; accepted October 3, 2005

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