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eCAM 2004 1(1):9-10; doi:10.1093/ecam/neh001
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© Oxford University Press, 2004.

Editorial

Equivalence and Non-inferiority Trials of CAM

Edzard Ernst

Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK

The first 10% of the full text of this article appears below.

For several reasons, the value of placebo-controlled trials has often been disputed (not only) in complementary/alternative medicine (CAM) (1). Many clinicians feel that giving placebos to suffering patients is unethical. In fact, the Declaration of Helsinki advocates placebo-controlled trials only for conditions for which no therapy of proven efficacy exists (2). Other frequently cited reasons against the use of placebos in controlled clinical trials include the notions that patients find them hard to accept, that the placebo effect is an important contributor to the overall therapeutic effect, which should be cultivated rather than eliminated, and that placebo effects . . . [Full Text of this Article]


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