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eCAM 2004 1(1):29-34; doi:10.1093/ecam/neh011
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© Oxford University Press, 2004.

Commentary

Commentary on CAM and NK Cells by Kazuyoshi Takeda and Ko Okumura

Edwin L. Cooper*

Professor and Editor-in-Chief, Laboratory of Comparative Neuroimmunology, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095–1763, USA

The first 150 words of the full text of this article appear below.


   History of Natural Killer (NK) cells is inextricably woven into the fabric of modern immunology: cells have it!
 
Innate and adaptive immunity: is innate immunity the hero?

The purpose of this commentary is to extend the ideas presented in the article by Takeda and Okumura (1) on Complementary and Alternative Medicine (CAM) and Natural Killer (NK) cells. Instances of unintentional omissions due to space and time constraints or possibilities of tracing evolutionary origins or using alternative models will be presented briefly. A second overarching concern is to bring the idea of NK cells into the broadest realm of biology, rendering NK cells, like all other living phenomena, accessible in the conceptual, organismic and universal sense. To arrive at this point historically would have been somewhat slower without the ferment that occurred in the world of immunology during the 1800s. As other aspects of history and culture reveal ideas, creations, writings and material concepts were quite different then from our current understanding. In addition, the interplay of events and various other forces, contrived or accidental, may . . . [Full Text of this Article]

Was the evolution of the vertebrate immune system necessary?

The development of modern immunology may owe itself to invertebrates

Organismic approaches are inclusive


   Tumor immunosurveillance by NK cells in animal models and humans
 
Early views on immunologic surveillance

Current views on cellular mediators against tumors


   NK cell receptors for tumor recognition
 
NK cell receptor NKG2D

Crystal structure of NKG2D and two adapters

NKG2D ligand receptor activates NK cells and macrophages inducing tumor immunity


   Toll-like receptors
 
Innate sensing

Toll in a protostome invertebrate: mosquito

Vertebrate ancestors: the tunicates typical deuterostomes


   Lectin receptors
 

   Perspectives on origins of immune system components
 
*Professor and Editor-in-Chief, Tel: (310) 825–9567; Fax: (310) 825–2224. E-mail: ecam@mednet.ucla.edu


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Related articles in eCAM:

CAM and NK Cells
Kazuyoshi Takeda and Ko Okumura
eCAM 2004 1: 17-27. [Abstract] [FREE Full Text]  



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