Skip Navigation



eCAM Advance Access published online on October 30, 2009
eCAM, doi:10.1093/ecam/nep178
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Tseng, S.-H.
Right arrow Articles by Wang, C.-C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tseng, S.-H.
Right arrow Articles by Wang, C.-C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Hypolipidemic Effects of Three Purgative Decoctions

Sung-Hui Tseng1, Ting-Yi Chien2, Jiun-Rong Chen3, I-Hsin Lin4 and Ching-Chiung Wang2

1School of Medicine, 2School of Pharmacy, 3School of Nutrition and Health Sciences Taipei Medical University, 250 Wu- Xing Street, Taipei 110 and 4Committee on Chinese Medicine and Pharmacy Department of Health, Executive Yuan 6 Shuang-cheng Street, Taipei 104, Taiwan, ROC

In traditional Chinese medicine (TCM), purgation is indicated when a person suffers an illness due to the accumulation of evil internal heat. Obese individuals with a large belly, red face, thick and yellow tongue fur, constipation, and avoidance of heat are thought accumulates of evil internal heat, and they are also treated with purgatives such as Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT), and Tiao-Wei-Chen-Chi-Tang (TWCCT) by TCM doctors. In previous studies, our group found that TCCT has potent anti-inflammatory activity, and that XCCT is an effective antioxidant. Since rhubarb is the principle herb in these three prescriptions, we will first present a thorough review of the literature on the demonstrated effect (or lack of effect) of rhubarb and rhubarb-containing polyherbal preparations on lipid and weight control. We will then continue our research with an investigation of the anti-obesity and lipid-lowering effect of TCCT, XCCT, TWCCT, and rhubarb extracts using two animal models. TWCCT lowered the serum triglyceride concentration as much as fenofibrate in Triton WR-1339-treated mice. Daily supplementation with XCCT and TWCCT significantly attenuated the high-fat-diet-induced hypercholesterolemia in rats. In addition, TWCCT also significantly lowered the high-fat-diet-induced hypertriglycemia. Although feeding high-fat diet rats with these extracts did not cause loose stools or diarrhea or other deleterious effects on renal or hepatic function. None of these extracts lowered the body weight of rats fed on high-fat diet. In conclusion, the results suggest that XCCT and TWCCT might exert beneficial effects in the treatment of hyperlipidemia.

Keywords: hyperlipidemia – obesity – rhubarb – Ta-Cheng-Chi-Tang – Tiao-Wei-Chen-Chi-Tang – Triton WR-1339 – Xiao-Chen-Chi-Tang

For reprints and all correspondence: Prof. Ching-Chiung Wang, School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wu-Xing Street Taipei 110, Taiwan, ROC. Tel: +886-2-27361661, Ext. 6161; Fax: +886-2-27329368; E-mail: crystal{at}tmu.edu.tw

Received January 19, 2009; accepted October 6, 2009


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.