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eCAM Advance Access published online on September 29, 2009
eCAM, doi:10.1093/ecam/nep149
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Protective Effects of Rosa damascena and its Active Constituent on Aβ(25–35)-induced Neuritic Atrophy

Suresh Awale1, Chihiro Tohda2, Yasuhiro Tezuka1, Makoto Miyazaki3 and Shigetoshi Kadota1

1Division of Natural Products Chemistry, 2Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama and 3Antianti Co. Ltd, Japan, 5-8 Hatago-Machi, Toyama, Japan

Dementia is a clinical syndrome characterized by multiple cognitive deficits and causes progressive neurodegeneration leading eventually to death. The incidence of dementia is increasing worldwide with the increase in ageing population. However, no effective treatment is available yet. It has been hypothesized that drugs activating neurite outgrowth might induce neuronal reconstruction and help in the recovery of brain function. Working on this hypothesis, we recently observed that the chloroform extract of the Rosa damascena significantly induced the neurite outgrowth activity and inhibited the Aβ(25–35)-induced atrophy and cell death. Further workup led the isolation of a very long polyunsaturated fatty acid having molecular formula C37H64O2 as an active constituent. The structure of this compound was established by extensive analysis of fragmentations observed in EI-MS mode. The isolated compound protected Aβ(25–35)-induced atrophy and displayed strong neurite outgrowth activity. The length of dendrite in the cells treated with this compound were comparable to those of nerve growth factor (NGF) treated cells.

Keywords: amyloid β(25–35) – dementia – dendrites – neurites – Rosa damascene – VLFAs

For reprints and all correspondence: Shigetoshi Kadota, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Tel: +81-76-434-7625; Fax: +81-76-434-5059; E-mail: kadota{at}inm.u-toyama.ac.jp

Received May 12, 2009; accepted August 30, 2009


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