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eCAM Advance Access published online on August 17, 2009
eCAM, doi:10.1093/ecam/nep115
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Paeoniae alba Radix Promotes Peripheral Nerve Regeneration

Kun-Shan Huang1, Jaung-Geng Lin1, Han-Chung Lee2, Fuu-Jen Tsai1, Da-Tian Bau1, Chih-Yang Huang1,3,*, Chun-Hsu Yao1,4,* and Yueh-Sheng Chen1,4,*

1Graduate Institute of Chinese Medical Science, China Medical University, 2Division of Neurosurgery, China Medical University Hospital, 3Department of Health and Nutrition Biotechnology, Asia University and 4Department Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats. At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml–1 had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group (P < 0.05). These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve.

Keywords: Paeoniae alba Radix – peripheral nerve regeneration – PC12 cell – silicone rubber

For reprints and all correspondence: Yueh-Sheng Chen, PhD, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Tel: +886-4-22053366. Ext. 3308; Fax: +886-4-22032295; E-mail: yuehsc{at}mail.cmu.edu.tw

*These authors contributed equally to this work.

Received March 25, 2009; accepted July 21, 2009


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