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eCAM Advance Access published online on August 17, 2009
eCAM, doi:10.1093/ecam/nep105
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In vitro and In vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract Against Salmonella

Jang-Gi Choi1, Ok-Hwa Kang1, Young-Seob Lee1, Hee-Sung Chae1, You-Chang Oh1, Obiang-Obounou Brice1, Min-San Kim1, Dong-Hwan Sohn2, Hun-Soo Kim3, Hyun Park3, Dong-Won Shin4, Jung-Rae Rho5 and Dong-Yeul Kwon1

1College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, 2Department of Pharmacy, College of Pharmacy, Wonkwang University, 3College of Medicine, Wonkwang University, Jeonbuk 570-749, 4Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742 and 5Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Republic of Korea

Punica granatum is commonly used in Korea as a traditional medicine for the treatment of pathogenic bacteria. In this study, we investigated the in vitro and in vivo antimicrobial activity of P. granatum peel EtOH extract (PGPE) against 16 strains of Salmonella. The minimal inhibitory concentrations of PGPE were in the range of 62.5–1000 µg ml–1. In addition, the in vivo antibacterial activity of the PGPE extract was examined in a S. typhimurium infection mouse model. Mice were initially infected with S. typhimurium and then with PGPE. The extract was found to have significant effects on mortality and the numbers of viable S. typhimurium recovered from feces. Although clinical signs and histological damage were rarely observed in the treated mice, the untreated controls showed signs of lethargy and histological damage in the liver and spleen. Taken together, the results of this study indicate that PGPE has the potential to provide an effective treatment for salmonellosis.

Keywords: antibacterial activity – Punica granatum peel – salmonella

For reprints and all correspondence: Dong-Yeul Kwon, PhD, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea. Tel: +82-63-850-6802; Fax: +82-63-852-6802; E-mail: sssimi{at}wku.ac.kr

Received December 10, 2008; accepted July 8, 2009


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