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eCAM Advance Access published online on July 10, 2009
eCAM, doi:10.1093/ecam/nep070
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity

Si-Yuan Pan1,*, Zhi-Ling Yu2,*, Hang Dong1,2, Chun-Jing Xiang1, Wang-Fun Fong2 and Kam-Ming Ko3

1Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102,2School of Chinese Medicine, Hong Kong Baptist University and 3Department of Biochemistry, Hong Kong University of Science & Technology, Hong Kong, China

Effects of the ethanol extract of Fructus Schisandrae (EtFSC) on serum and liver lipid contents were investigated in mice fed with high fat/cholesterol (HFC) diet for 8 or 15 days. The induction of hypercholesterolemia by HFC diet caused significant increases in serum and hepatic total cholesterol (TC) levels (up to 62% and 165%, respectively) and hepatic triglyceride (TG) levels (up to 528%) in mice. EtFSC treatment (1 or 5 g/kg/day for 7 days; from Day 1 to 7 or from Day 8 to 14, i.g.) significantly decreased the hepatic TG level (down to 35%) and slightly increased the hepatic index (by 8%) in hypercholesterolemic mice. Whereas fenofibrate treatment (0.1 g/kg/day for 7 days, i.g.) significantly lowered the hepatic TG level (by 61%), it elevated the hepatic index (by 77%) in hypercholesterolemic mice. Acute toxicity test showed that EtFSC was relatively non-toxic, with an LD50 value of 35.63 ± 6.46 g/kg in mice. The results indicate that EtFSC treatment can invariably decrease hepatic TG in hypercholesterolemic mice, as assessed by both preventive and therapeutic protocols, suggesting its potential use for fatty liver treatment.

Keywords: Schisandra chinensis – fenofibrate – hypercholesterolemia – fatty liver – hepatic index

For reprints and all correspondence: Si-Yuan Pan, Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China. Tel: +86-10-84738626; Fax: +86-10-84738627; E-mail: siyuan-pan{at}163.com; zlyu{at}hkbu.edu.hk

*These authors equally contributed to this work.

Received November 27, 2008; accepted May 28, 2009


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