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eCAM Advance Access first published online on July 13, 2009
This version published online on July 15, 2009
eCAM, doi:10.1093/ecam/nep069
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

The Budding Yeast ‘Saccharomyces cerevisiae’ as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

Bouchra Qaddouri1, Abdelkarim Guaadaoui1, Ahmed Bellirou1, Abdellah Hamal1, Ahmed Melhaoui2, Grant W. Brown3,4 and Mohammed Bellaoui1,5

1Laboratoire de Génétique et Biotechnologies, 2Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda 60000, Morocco, 3Department of Biochemistry, 4Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 1A8, Canada and 5Faculté Pluridisciplinaire de Nador, Université Mohamed Premier, B.P: 300 Selouane 62700, Morocco

The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.

Keywords: anticancer agents – mechanisms of action – medicinal plants – toxicity screen

For reprint and all correspondence: Mohammed Bellaoui, Faculté Pluridisciplinaire de Nador, Université Mohamed Premier, B.P: 300 Selouane 62700, Morocco. Tel: +212-72-09-70-69; Fax: +212-36-50-06-03; E-mail: bmbellaoui{at}gmail.com

Received November 25, 2008; accepted May 28, 2009


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