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eCAM Advance Access published online on June 26, 2009
eCAM, doi:10.1093/ecam/nep059
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abnormal Savda Munziq, an Herbal Preparation of Traditional Uighur Medicine, may Prevent 1,2-dimethylhydrazine-induced Rat Colon Carcinogenesis

Abdiryim Yusup1, Halmurat Upur1, Anwar Umar1, Benedicte Berke1,2, Dilxat Yimit1, Jaya Conser Lapham1, Nicholas Moore1,2 and Pierrette Cassand3

1Faculty of Traditional Uighur Medicine, Xinjiang Medical University, 830011 Urumqi, China,2Department of Pharmacognosy, University Victor Segalen Bordeaux 2, 33076 Bordeaux and 3Laboratory of Food and Colon Carcinogenesis, University Bordeaux 1, 33405 Talence, France

The study tried to assess the chemoprotective effect of abnormal Savda Munziq (ASMq) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Male F344 rats were randomized into eight groups: Group 1 was served as control, no DMH injection was given and treated daily with normal saline. Rats in Groups 2–8 were given a single intraperitoneal injection of DMH (20 mg/kg body weight) at the beginning of the study. Group 2 was served as negative control, administered with normal saline until the end of the experiment after the single DMH injection. Groups 3–5 were served as pretreatment group, administered with ASMq ethanol extract at 400, 800 and 1600 mg/kg body weight, respectively, until the 45th day, continued by normal saline administration for another 45 days. Groups 6–8 were served as the treatment group, administered with normal saline for the first 45 days from the day of DMH injection, ASMq ethanol extract at three different doses to be administered until the end of the second 45th day. All rats were sacrificed at 91st day and the colons were analyzed for aberrant crypt foci (ACF) formation and crypt multiplicity. Results showed that ASMq ethanol extract reduced the number of ACF, AC and crypt multiplicity significantly (P < 0.05). It suggested that ASMq ethanol extract had chemoprotective effects on DMH-induced colon carcinogenesis, by suppressing the development of preneoplastic lesions, and probably exerted protection against the initiation and promotion steps of colon carcinogenesis.

Keywords: aberrant crypt foci – abnormal Savda Munziq – colon carcinogenesis – 1,2-dimethylhydrazine

For reprints and all correspondence: Dr Halmurat Upur, Faculty of Traditional Uighur Medicine, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, Xinjiang, China. Tel: +86-991-43-66-176; Fax: +86-991-43-66-014; E-mail: halmurat{at}263.net

Received July 3, 2008; accepted May 12, 2009


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