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eCAM Advance Access published online on June 22, 2009
eCAM, doi:10.1093/ecam/nep039
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by in vivo Excision and Incision Models

Esra Küpeli Akkol1, Ufuk Koca1, Ipek Pesin1 and Demet Yilmazer2

1Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330 and 2Department of Pathology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey

Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol®. The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol® (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated that A. biebersteinii displayed remarkable wound healing activity.

Keywords: Achillea biebersteinii – Asteraceae – excision – incision – tensiometer – wound healing

For reprints and all correspondence: Esra Küpeli Akkol, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey. Tel: +90 312 2023185; Fax: +90 312 2235018; E-mail: esrak{at}gazi.edu.tr

Received December 10, 2008; accepted April 7, 2009


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