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eCAM Advance Access published online on April 6, 2009
eCAM, doi:10.1093/ecam/nep027
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice

Heng-Yuan Chang1,*, Ming-Jyh Sheu2,*, Chun-Hung Yang3, Tsung-Chun Lu1, Yuan Shiun Chang1, Wen-Huang Peng1, Shyh-Shyun Huang1 and Guan-Jhong Huang1

1Institute of Chinese Pharmaceutical Sciences, 2School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404 and 3Department of Pesticide Toxicology, Taiwan Agricultural Chemicals and Toxic substances Research institute, Wu Feng, Taichung 433, Taiwan

Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects. Treatment of male ICR mice with hispolon (10 and 20 mg/kg) significantly inhibited the numbers of acetic acid-induced writhing response. Also, our result showed that hispolon (20 mg/kg) significantly inhibited the formalin-induced pain in the later phase (P < 0.01). In the anti-inflammatory test, hispolon (20 mg/kg) decreased the paw edema at the fourth and fifth hour after {lambda}-carrageenin (Carr) administration, and increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver tissue. We also demonstrated that hispolon significantly attenuated the malondialdehyde (MDA) level in the edema paw at the fifth hour after Carr injection. Hispolon (10 and 20 mg/kg) decreased the nitric oxide (NO) levels on both the edema paw and serum level at the fifth hour after Carr injection. Also, hispolon (10 and 20 mg/kg) diminished the serum TNF-{alpha} at the fifth hour after Carr injection. The anti-inflammatory mechanisms of hispolon might be related to the decrease in the level of MDA in the edema paw by increasing the activities of SOD, GPx and GRx in the liver. It probably exerts anti-inflammatory effects through the suppression of TNF-{alpha} and NO.

Keywords: analgesic – anti-inflammation – Hispolon – malondialdehyde – nitric oxide – superoxide dismutase – TNF-{alpha}

For reprints and all correspondence: Guan-Jhong Huang, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. R.O.C. Tel: +886-4-2205-3366. Ext: 5508; Fax: +886-4-2208-3362, E-mail: gjhuang{at}mail.cmu.edu.tw

*These two authors contributed equally to this work.

Received October 29, 2008; accepted March 3, 2009


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