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eCAM Advance Access published online on February 27, 2009
eCAM, doi:10.1093/ecam/nep015
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wound Healing Activity of Topical Application Forms Based on Ayurveda

Hema Sharma Datta1, Shankar Kumar Mitra2 and Bhushan Patwardhan1

1Interdisciplinary School of Health Sciences, University of Pune, Ganeshkhind, Pune 411007, India and 2The Himalaya Drug Company, Makali, Bangalore 562 123, India

The traditional Indian medicine—Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil, Phyllanthus emblica fruits, Shorea robusta resin, Yashada bhasma as study materials. For preliminary efficacy evaluation of the anti-aging activity we chose excision and incision wound healing animal models and studied the parameters including wound contraction, collagen content and skin breaking strength which in turn is indicative of the tissue cell regeneration capacity, collagenation capacity and mechanical strength of skin. The group treated with the formulations containing Yashada bhasma along with Shorea robusta resin and flax seed oil showed significantly better wound contraction (P<0.01), higher collagen content (P < 0.05) and better skin breaking strength (P<0.01) as compared to control group; thus proposing them to be effective prospective anti-aging formulations.

Keywords: anti-aging – Ayurveda – flax seed oil – Phyllanthus emblica – Shorea robusta – wound healing – zinc

For reprints and all correspondence: Bhushan Patwardhan, Chief Academics, Manipal Education, 14 Airport Road, Manipal Towers, Bangalore - 560 008, India. Tel: 91 80 25202304; Ext. 149; Fax: +91 80 25202250; E-mail: bhushan.patwardhan{at}manipalu.com

Present address: Bhushan Patwardhan, Manipal Education, 14 Airport Road, Manipal Towers, Bangalore 560 008, India

Received July 25, 2008; accepted January 16, 2009


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