Skip Navigation



eCAM Advance Access published online on February 8, 2009
eCAM, doi:10.1093/ecam/nep013
This Article
Right arrow Full Text Freely available
Right arrow Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Yang, G.
Right arrow Articles by Lin, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, G.
Right arrow Articles by Lin, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Protective Effects of Chinese Traditional Medicine Buyang Huanwu Decoction on Myocardial Injury

Guangde Yang1, Zhiyuan Fang1,2, Yu Liu1, Hui Zhang1, Xiaolian Shi1, Qiaoli Ji1, Qinqin Lin1 and Rong Lin1

1Department of Pharmacology and Pharmacy, Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, School of Medicine, Xi’an, Shaanxi 710061 and 2Shaanxi Provincial People's Hospital, Xi’an, Shaanxi 710068, P.R. China

Many clinical studies have reported that Buyang Huanwu Decoction (BYHWD) has a protective effect on ischemic heart disease (IHD). In the present study, the protective effect of BYHWD on myocardial ischemia was investigated. Different doses of BYHWD and Compound Danshen Dropping Pills (CDDP) were lavaged to rats respectively, isoproterenol (ISO) was intraperitoneally injected in to all animals to induce myocardial ischemia except the control group. Electrocardiogram (ECG) of each animal was recorded; activities of lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate aminotransferase (AST) in serum were detected. As the results of ECG showed, pre-treatment with BYHWD inhibited ischemic myocardial injury, and the activities of LDH, CK and AST were lower than those in the myocardial ischemia model group, which suggests that BYHWD rescues the myocardium from ischemia status. To research the potential mechanism, the level of nitric oxide (NO), nitric oxide syntheses (NOS) and inducible nitric oxide syntheses (iNOS), the expression of iNOS and ligand of cluster of differentiation 40 (CD40L) were detected. The results revealed that BYHWD significantly decreased the level of NO, NOS and iNOS in serum. Moreover, BYHWD decreased the expression of iNOS and CD40L in myocardial tissues. These results indicate that the protective effect of BYHWD on myocardial ischemia and mechanism are associated with inhibition of iNOS and CD40L expression.

Keywords: Buyang Huanwu Decoction – isoproterenol – ligand of cluster of differentiation 40 – myocardial ischemia – nitric oxide

For reprints and all correspondence: Rong Lin, Department of Pharmacology, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi 710061, P.R. China, Tel: +86-29-8265-7691; Fax: +86-29-8265-7833; E-mail: linrong08{at}hotmail.com

Received September 20, 2008; accepted January 13, 2009


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.