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eCAM Advance Access published online on February 10, 2009
eCAM, doi:10.1093/ecam/nep012
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© 2009 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus

Tsutomu Shimada1, Tomoko Akase1,2, Mitsutaka Kosugi3 and Masaki Aburada1

1Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shin-machi, Nishi-Tokyo-shi, Tokyo, 202-8585, 2Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 and 3Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, and Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan

‘Boiogito’ is a Kampo preparation which has been used since ancient times in patients with obesity of the ‘asthenic constitution’ type, so-called ‘watery obesity’, and its effect has been recognized clinically. In this study, we investigated the anti-obesity effect of Boiogito in the TSOD (Tsumura Suzuki Obese Diabetes) mouse, a model of spontaneous obese type II diabetes mellitus. Boiogito showed a significant anti-obesity effect in TSOD mice by suppressing body weight gain in a dosage-dependent manner. In addition, Boiogito showed significant ameliorative effects on features of metabolic syndrome such as hyperinsulinemia, fasting hyperglycemia and abnormal lipid metabolism. Regarding lipid accumulation in TSOD mice, Boiogito showed a significant suppressive effect on accumulation of subcutaneous fat, but the effect on the visceral fat accumulation that constitutes the basis of metabolic syndrome was weak, and the suppressive effect on insulin resistance was also weak. Furthermore, Boiogito did not alleviate the abnormal glucose tolerance, the hypertension or the peripheral neuropathy characteristically developed in the TSOD mice. In contrast, in the TSNO (Tsumura Suzuki Non-Obesity) mice used as controls, Boiogito suppressed body weight gain and accumulation of subcutaneous and visceral fat. The above results suggested that Boiogito is effective as an anti-obesity drug against obesity of the ‘asthenic constitution’ type in which subcutaneous fat accumulates, but cannot be expected to exert a preventive effect against various symptoms of metabolic syndrome that are based on visceral fat accumulation.

Keywords: anti-obesity – asthenic constitution – watery obesity – Kampo medicine – metabolic syndrome

For reprints and all correspondence: Masaki Aburada, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20, Shin-machi, Nishi-Tokyo-shi, Tokyo, 202-8585. Tel: +81-424-68-9178; Fax: +81-424-68-9178; E-mail: aburada{at}musashino-u.ac.jp

Received September 8, 2008; accepted January 12, 2009


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