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eCAM Advance Access published online on December 17, 2008
eCAM, doi:10.1093/ecam/nen077
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

C. T. Higuchi1, M. Sannomiya2, F. R. Pavan1, S. R. A. Leite2, D. N. Sato3, S. G. Franzblau4, L. V. S. Sacramento1, W. Vilegas2 and C. Q. F. Leite1

1Unesp, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú km 01, CEP 14801-902, Araraquara – SP, Brasil, 2Unesp, Universidade Estadual Paulista, Instituto de Química, Rua Francisco Degni s/n. Bairro Quitandinha, C.P.335. CEP 14800-900 Araraquara – SP, Brasil, 3Instituto Adolfo Lutz, Laboratório de Micobacteriologia, Rua Minas, 887, CEP 14085-410, Ribeirão Preto, SP, Brasil and 4Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, USA

Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration—MIC, 62.5 µg ml–1), triterpenoids as bassic acid (MIC = 2.5 µg ml–1), {alpha}-amyrin acetate (MIC = 62.5 µg ml–1), a mixture of lupeol, {alpha}- and β-amyrin (MIC = 31.5 µg ml–1) and a mixture of lupeol, and acetates of {alpha}- and β-amyrin (MIC = 31.5 µg ml–1). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).

Keywords: antimycobacterial activity – bassic acid – Byrsonima fagifolia – dotriacontane – Malpighiaceae – triterpenes – tuberculosis

For reprints and all correspondence: C. Q. F. Leite, Unesp, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú km 01, CEP 14801-902, Araraquara – SP, Brasil. Tel: 55-16-33016053; Fax: 55-16-33016940; E-mail: leitecqf{at}fcfar.unesp.br

Received June 28, 2008; accepted November 14, 2008


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