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eCAM Advance Access published online on February 27, 2008
eCAM, doi:10.1093/ecam/nen018
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Effects of Satureja khuzestanica on Serum Glucose, Lipids and Markers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Trial

Sanaz Vosough-Ghanbari1, Roja Rahimi1, Shabnam Kharabaf1, Shima Zeinali1, Azadeh Mohammadirad1, Somayeh Amini2, Nargues Yasa3, Alinazar Salehnia1, Tayebeh Toliat1, Shekoufeh Nikfar4, Bagher Larijani2 and Mohammad Abdollahi1

1Faculty of Pharmacy and Pharmaceutical Sciences Research Center (PSRC), 2Endocrinology and Metabolism Research Center (EMRC) and Faculty of Medicine, 3Medicinal Plants Research Center (MPRC), Tehran University of Medical Sciences (TUMS) and 4Drug Selecting Committee, Food and Drug Organization, and Food and Drug Laboratory Research Center, Tehran, Iran

Satureja khuzestanica is an endemic plant of Iran that is widely distributed in the Southern part of the country. It has antioxidant properties and thus it seems to be useful in diseases related to oxidative stress such as diabetes and hyperlipidemia. The present study investigates the effect of S. khuzestanica supplement in metabolic parameters of hyperlipidemic patients with type 2 diabetes mellitus. Twenty-one hyperlipidemic patients with type 2 diabetes mellitus were randomized in a double blind, placebo controlled clinical trial to receive either S. khuzestanica (tablets contain 250 mg dried leaves) or placebo once a day for 60 days. Blood samples were obtained at baseline and at the end of the study. Samples were analyzed for levels of glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, creatinine, thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxidation and ferric reducing ability (total antioxidant power, TAP). Treatment of patients by S. khuzestanica for 60 days induced significant decrease in total cholesterol (P = 0.008) and LDL-cholesterol (P = 0.03) while increased HDL-cholesterol (P = 0.02) and TAP (P = 0.007) in comparison with the baseline values. S. khuzestanica did not alter blood glucose, triglyceride, creatinin and TBARS levels. In comparison with baseline values, no significant change was observed in blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, creatinine, TBARS and TAP in placebo-treated group. Usage of S. khuzestanica as a supplement to drug regimen of diabetic type 2 patients with hyperlipidemia is recommended.

Keywords: hyperlipidemia – oxidative stress – Satureja khuzestanica – type 2 diabetes mellitus

For reprints and all correspondence: Prof. Mohammad Abdollahi, Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Iran. Tel: +98-21-66959104; Fax: +98-21-66959104; E-mail: mohammad{at}tums.ac.ir

Received July 2, 2007; accepted February 14, 2008


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