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eCAM Advance Access published online on February 4, 2008
eCAM, doi:10.1093/ecam/nen001
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

Vishnu Kumar1, Mohammad Mubin Khan2, Ashok Kumar Khanna2, Ranjana Singh3, Sushma Singh3, Ramesh Chander3, Farzana Mahdi1, Abbas Ali Mahdi3, Jitendra Kumar Saxena2 and Raj Kumar Singh3

1Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, Division of Biochemistry, Central Drug Research Institute, Lucknow-226001 and 3Department of Biochemistry, King George's Medical University, Lucknow-226003, India

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg–1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 µM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.

Keywords: Anthocephalus indicus – hypolipidemic agent – oxygen free radical scavengers – plant antioxidant – Rubiaceae – triton model of hyperlipidemia

For reprints and all correspondence: Dr Raj Kumar Singh, Senior Professor & Head, Department of Biochemistry, King George's Medical University, Lucknow-226003, India. Tel: +91-522-2257449; Fax: +91-522-2257539; E-mail: singhrk23a{at}hotmail.com

Received July 10, 2007; accepted December 17, 2007


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