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eCAM Advance Access published online on October 27, 2007
eCAM, doi:10.1093/ecam/nem160
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In vitro Evaluation of the Antiviral Activity of an Extract of Date Palm (Phoenix dactylifera L.) Pits on a Pseudomonas Phage

Sabah A. A. Jassim and Mazen A. Naji

Department of Microbiology, Zayed Complex for Herbal Research and Traditional Medicine, General Authority for Health Services for the Emirate of Abu Dhabi

A crude acetone extract of the pit of date palm (Phoenix dactylifera L.) was prepared and its antiviral activity evaluated against lytic Pseudomonas phage ATCC 14209-B1, using Pseudomonas aeruginosa ATCC 25668 as the host cell. The antiviral activity of date pits was found to be mediated by binding to the phage, with minimum inhibitory concentration (MIC) of <10 µg ml–1. The decimal reduction time (D-values), the concentration exponent ({eta}) and the phage inactivation kinetics were determined. The date pit extracts show a strong ability to inhibit the infectivity of Pseudomonas phage ATCC 14209-B1 and completely prevented bacterial lysis, which it is hoped will promote research into its potential as a novel antiviral agent against pathogenic human viruses.

Keywords: antiviral – bacteriophage – CAM – MIC – phage – Phoenix dactylifera L. – Pseudomonas aeruginosa

For reprints and all correspondence: Prof. Sabah A. A. Jassim, Department of Microbiology, Zayed Complex for Herbal Research and Traditional Medicine, General Authority for Health Services for the Emirate of Abu Dhabi. Tel: +9712 4491401; Fax: +9712 4490132; E-mail: profjassim{at}yahoo.co.uk

Received April 24, 2007; accepted September 13, 2007


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