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eCAM Advance Access published online on October 22, 2007
eCAM, doi:10.1093/ecam/nem158
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Acori graminei rhizoma Ameliorated Ibotenic Acid-Induced Amnesia in Rats

Ji Hyun Kim1, Dae-Hyun Hahm2, Hye-Jung Lee2, Kwang Ho Pyun3 and Insop Shim3

1Immunology and Cell Biology Core Laboratory, Catholic Research Institutes of Medical Science, The Catholic University of Korea, Seoul 137-701, 2Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University, Suwon, 3Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea

In the present study, we investigated the effects of Acori graminei rhizoma (AGR) on learning and memory for the Morris water maze task and on the central cholinergic system of the rats with excitotoxic medial septum (MS) lesion. On the water maze test, the rats were trained to find a platform that was in a fixed position during 6 days and then they received a 60 s probe trial in which the platform was removed from the pool on the 7th day. Ibotenic lesioning of the MS impaired the performance on the maze test and it caused degeneration of choline acetyltransferase and acetylcholine esterase in the hippocampus, which are markers of the central cholinergic system. Daily administrations of AGR (100 mg kg–1, i.p.) for 21 consecutive days produced reversals of the ibotenic acid-induced deficit in learning and memory. These treatments also reduced the loss of cholinergic immunoreactivity in the hippocampus that was induced by ibotenic acid. These results demonstrated that AGR ameliorated learning and memory deficits through their effects on the central nervous system, and neuroprotection was partly evaluated through the effect of AGR on the cholinergic system. Our studies suggest that AGR can possibly be used as treatment for Alzheimer's disease.

Keywords: Acori graminei rhizome – learning and memory – central cholinergic system – neuroprotection

For reprints and all correspondence: Insop Shim, Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul 137-701, Korea. Tel: +82 2 590 2971; Fax: +82 2 592 6359; E-mail: ishim{at}catholic.ac.kr

Received July 5, 2006; accepted September 20, 2007


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