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eCAM Advance Access published online on October 25, 2007
eCAM, doi:10.1093/ecam/nem127
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf

B. Shivananda Nayak1, Steve Sandiford1 and Anderson Maxwell2

1Department of Pre clinical Sciences, Biochemistry unit, Faculty of Medical Sciences and 2Department of Life Sciences, Chemistry Unit, Faculty of Science and Agriculture, The University of the West Indies, St Augustine, Trinidad

Morinda citrifolia L. (noni) is one of the most important traditional Polynesian medicinal plants. The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing. The ethanol extract of noni leaves (150 mg kg–1 day–1) was used to evaluate the wound-healing activity on rats, using excision and dead space wound models. Animals were randomly divided into two groups of six for each model. Test group animals in each model were treated with the ethanol extract of noni orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, time until complete epithelialization, granulation tissue weight and hydoxyproline content. On day 11, the extract-treated animals exhibited 71% reduction in the wound area when compared with controls which exhibited 57%. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002). Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content and histological characteristics suggest that noni leaf extract may have therapeutic benefits in wound healing.

Keywords: excision and dead space wound – hydroxyproline – Morinda citrifolia – wound healing

For reprints and all correspondence: Dr B. Shivananda Nayak, Department of Pre clinical Sciences, Biochemistry unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad. Tel: 001-868-6621873-4641; Fax: 001- 868-6621873; E-mail: shiv25{at}gmail.com

Received January 29, 2007; accepted July 10, 2007


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