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eCAM Advance Access published online on November 8, 2007
eCAM, doi:10.1093/ecam/nem118
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Anti-inflammatory and Immune-regulatory Effects of Subcutaneous Perillae Fructus Extract Injections on OVA-induced Asthma in Mice

Yun-Kyoung Yim1, Hyun Lee2, Kwon-Eui Hong2, Young-Il Kim2, Seung-Kyoung Ko2, Jung-Eun Kim1, Seung-Yong Lee1 and Kwang-Suk Park3

1Department of Meridian & Acupoint, 2Department of Acupuncture, College of Oriental Medicine, Daejeon University, South Korea, and 3Department of Biomedical Engineering, College of Medicine, Seoul National University, South Korea

Perillae fructus (perilla seed) is a traditional medicinal herb used to treat bronchial asthma in Oriental medical clinics. ST36 is one of the most widely used acupuncture points, particularly for immune system regulation. Injection of an herbal extract into an acupuncture point (herbal acupuncture) is a therapeutic technique combining both acupuncture and herbal treatment. Perillae fructus extract was injected subcutaneously (Perillae fructus herbal acupuncture; PF-HA) at acupoint ST36 of OVA-induced asthmatic mice. The lung weight, bronchoalveolar fluid (BALF) cell count, the number of CCR3+, CD11b+, CD4+ and CD3e+/CD69+ cells in the lung, and the level of IgE, IL-4, IL-5 and IL-13 in BALF and serum were then measured. RT-PCR was used to measure the mRNA expression of IL-4, IL-5, IL-13 and TNF-{alpha} in the lung. Lung sections were analyzed histologically. PF-HA significantly reduced lung weight, the number of inflammatory cells in the lung and BALF, the levels of IgE and Th2 cytokines in BALF and serum, mRNA expression of Th2 cytokines in the lung, and pathological changes in lung tissue. Our results suggest that PF-HA may have an anti-inflammatory and immune-regulatory effect on bronchial allergic asthma by restoring the Th1/Th2 imbalance in the immune system and suppressing eosinophilic inflammation in airways.

Keywords: herbal acupuncture – OVA-induced asthma – perillae fructus – ST36

For reprints and all correspondence: Yun-Kyoung Yim, OMD, PhD, Assistant Professor, Department of Meridian & Acupoint, College of Oriental Medicine, Daejeon University, #12407, 96-3, Yongun-dong, Dong-gu, Daejeon, 300-716, South Korea. Tel: (82)11-9421-2610; Fax: (82)42-280-2610; E-mail: docwindy{at}dju.ac.kr

Received October 11, 2005; accepted July 16, 2007


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