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eCAM Advance Access published online on October 10, 2007
eCAM, doi:10.1093/ecam/nem103
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Modified Wendan Decoction can Attenuate Neurotoxic Action Associated with Alzheimer's Disease

Ping Liu1, Lei Zhao2, Shu-Ling Zhang2 and Ji-Zhou Xiang1

1Faculty of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 and 2Department of Hepatology and Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China

We observed the effect of modified Wendan decoction (modified Wen-Dan-Tang) on a cellular model of Alzheimer's disease. Amyloid beta (Aß) 25–35 segment neurotoxin was employed to induce a PC12 cellular model of Alzheimer's disease. After modified Wendan decoction was fed to rats, the serum containing medicine was prepared and changes in cell morphology observed. Cell mortality and survival rate was examined by trypan blue stain assay and MTT method and caspase-3 expression was detected by western blot, while cell apoptosis was examined by flow cytometry. Cell morphology of prepared serum group was better than that of controls, and cell survival rate in prepared serum group was higher than that in control (P < 0.01 or P < 0.05). Cell mortality, caspase-3 expression and apoptosis rate in prepared serum group were lower than that in control (P < 0.01 or P < 0.05). We conclude that Modified Wendan Decoction can attenuate the neurotoxicity of Aß 25–35 and rescue neurons via suppressing apoptotic process.

Keywords: Alzheimer's disease – apoptosis – Aß – caspase-3 – herbal medicine – PC12 cell

For reprints and all correspondence: Dr Lei Zhao, Department of Hepatology and Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. Tel: +86-27-62717387; Fax: +86-27-84848153; E-mail: chinesemd{at}hotmail.com

Received March 14, 2007; accepted July 3, 2007


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