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eCAM Advance Access published online on October 4, 2007
eCAM, doi:10.1093/ecam/nem098
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae)

S. A. Adesegun1, A. Fajana1, C. I. Orabueze1 and H. A. B. Coker2

1Department of Pharmacognosy and 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, PMB 12003, Lagos, Nigeria

The antioxidant activities of crude extract of Phaulopsis fascisepala leaf were evaluated and compared with {alpha}-tocopherol and BHT as synthetic antioxidants and ascorbic acid as natural-based antioxidant. In vitro, we studied its antioxidative activities, radical-scavenging effects, Fe2+-chelating ability and reducing power. The total phenolic content was determined and expressed in gallic acid equivalent. The extract showed variable activities in all of these in vitro tests. The antioxidant effect of P. fascisepala was strongly dose dependent, increased with increasing leaf extract dose and then leveled off with further increase in extract dose. Compared to other antioxidants used in the study, {alpha}-Tocopherol, ascorbic acid and BHT, P. fascisepala leaf extract showed less scavenging effect on {alpha},{alpha},-diphenyl-ß-picrylhydrazyl (DPPH) radical and less reducing power on Fe3+/ferricyanide complex but better Fe2+-chelating ability. These results revealed the in vitro antioxidant activity of P. fascisepala. Further investigations are necessary to verify these activities in vivo.

Keywords: iron chelating power – phenolic content – radical scavenging – reducing power

For reprints and all correspondence: Dr S. A. Adesegun, Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, PMB 12003, Lagos, Nigeria. Tel: 234-1-8035995080; Fax: 234-1-5851432; Email: asegun67{at}yahoo.com

Received September 4, 2006; accepted May 8, 2007


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